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Medication that inhibit CYP2D6 activity, such as paroxetine and quinidine, may lead to lowered clearance of oxycodone which may lead to a rise in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in a rise in oxycodone Cmax by 11%, AUC by thirteen%, and t½ elim.Just like all opioid preparations, oxycodone products an